MHRN III Pilot Project 1: Stakeholder Views on Implementation of Suicide Risk Prediction Models

Grant Details

Funder: NIMH

Grant Number: U19MH121738

Grant Period: 09/24/2019 – 6/30/2021

Narrative: Age-adjusted suicide rates have been increasing in the U.S. over the past two decades. In 2017, more than 47,000 Americans died of suicide. Health care visits represent opportunities for suicide prevention because most individuals make an outpatient health care visit within a year of their suicide death and almost half have a visit within a month of their death. However, suicide risk is not always easily recognizable to clinicians—traditional clinical prediction is hardly better than chance. Predictive modeling that identifies patterns in “big data” from administrative and electronic health records has proven superior to clinical suicide risk prediction and routinely used suicide screening instruments. While predictive modeling holds promise for suicide prevention, how models should be implemented in routine clinical practice and the contextual factors that influence their use are understudied. The potential benefits of any risk prediction model, including those designed to identify suicide risks, are dependent on making sure that the models are deployed in a manner that does not harm patients, supports clinical care management, and is sustainable for health care delivery systems. We propose a pre-implementation pilot study in three settings, using one-on-one, in-depth interviews to explore health system administrators’, clinicians’, and patients’ expectations, experiences with, concerns, and suggestions for the early use of suicide risk prediction models. In the first setting, health system administrators are still considering what might be the best implementation approach. Interviews will help us understand how various stakeholder expectations match what is actually occurring in the two other settings where small pilot studies will be in process. One of these settings is planning outreach to high-risk patients independent of health care visits while the other is planning delivery of risk scores at the point of care. By studying different implementation strategies, we can compare relative advantages and disadvantages. We are particularly interested in effects on clinical workflows, clinician-patient relationships, and patient experiences. While there is an emerging literature supporting the promise of predictive models in health care, implementation factors and patient impacts have been largely ignored. Yet decisions regarding design and modeling methods and implementation processes should be driven by stakeholder requirements. Results of this pilot study will have important clinical implications and will not only inform large-scale implementation of suicide risk prediction models in health systems across the country but will also inform development of future risk prediction models and associated care processes tailored to stakeholders needs more generally (not limited to suicide risk). The long-term goals of this pilot project are to inform ongoing health system-level efforts to reduce suicide prevalence and prevent suicides by optimizing the use of suicide risk prediction tools.

  • Lead Site:
    • Overall PI: KPNW (Bobbi Jo Yarborough)
  • Participating Sites/Subcontractors:
    • HPI (site project lead Rebecca Rossom)
    • KPWA (site project lead Julie Richards; site PI Greg Simon)
  • Funder Contacts
    • Science Officer: Susan Azrin
    • Program Official: Michael Freed
    • Grants Management Official: Julie Bergerud

Documents

Funding Announcement

Notice of Award

Personnel Contact List

Current Status

We have completed and analyzed interviews with 10 health care administrators, 30 clinicians in behavioral health departments, and 62 patients across three health systems.

Summary of Findings

Administrators and clinicians

  • Use of a suicide risk prediction model and two differing implementation approaches were acceptable.
  • Clinicians desired opportunities for input on implementation decision-making.
  • They wanted to know how this manner of risk identification enhanced existing suicide prevention efforts.
  • They wanted additional training on how the models determined risk and why some patients appeared at risk while others do not.
  • Clinicians were concerned about lack of suicide prevention resources for newly identified patients.
  • They wanted clear procedures for situations when they could not reach patients or when patients remained at-risk over a sustained period.
  • They would like consolidated suicide risk information in a dedicated module in the EHR to increase efficiency.

Patients

  • Patients were generally supportive of suicide risk prediction models derived from EHR data.
  • Concerns included: 1) apprehension about inducing anxiety and suicidal thoughts, or 2) triggering coercive treatment, particularly among those who reported prior negative experiences seeking mental health care.
  • Participants engaged in mental health care or case management expected to be asked about suicide risk and largely appreciated suicide risk conversations
  • Patients preferred conversations to come from clinicians comfortable discussing suicidality.

Publications

Yarborough BJH, Stumbo SP. Patient perspectives on acceptability of, and implementation preferences for, use of electronic health records and machine learning to identify suicide risk. Gen Hosp Psychiatry. 2021 May-Jun;70:31-37. doi: 10.1016/j.genhosppsych.2021.02.008.

Yarborough BJH, Stumbo SP, Schneider JL, Richards JE, Hooker SA, Rossom RC . Patient expectations of and experiences with a suicide risk identification algorithm in clinical practice. BMC Psychiatry. 2022 Jul 23;22(1):494. doi: 10.1186/s12888-022-04129-1 .

MHRN III Infrastructure: Administrative Core

Grant Details

Funder: NIMH

Grant Number: U19MH121738

Grant Period: 09/23/2019 – 06/30/2020

  • Narrative:​ Practice-based research has the potential to dramatically improve the speed, efficiency, relevance, and impact of mental health clinical and services research.  Mental Health Research Network (MHRN) III will include 14 research centers embedded in health systems serving a combined population of over 25 million patients in 16 states.  MHRN infrastructure will be enhanced to support a next-generation practice-based network, including:
    • Increased engagement of patients, health system leaders, and other stakeholders in network governance
    • An expanded public, open-source library of software tools and other technical resources
    • More formal processes for conducting feasibility pilot projects and rapid response to stakeholder queries
    • Expanded outreach to external stakeholders and research partners
  • Lead Site: KPWHRI
    • Overall PI: Greg Simon
  • Participating Sites/Subcontractors:
    • Baylor Scott & White – Site PI: Katherine Sanchez
    • Cornell University – Site PI: Jyotishman Pathak
    • Essentia Institute of Rural Health – Site PI: Stephen Waring
    • Georgia State University – Site PI: Ashli Owen-Smith
    • Harvard Pilgrim – Site PI: Christine Lu
    • HealthPartners – Site PI: Rebecca Rossom
    • Henry Ford Health System – Site PI Brian Ahmedani
    • KP Colorado – Site PI: Arne Beck
    • KP Georgia – Site PI Courtney McCracken
    • KP Hawaii – Site PI: Yihe Daida
    • KP Northern California – Site PI: Stacy Sterling
    • KP Northwest – Site PI: Frances Lynch
    • KP Southern California – Site PI: Karen Coleman
    • PalAlto Medical Foundation – Site PI: Ellis Dillon
  • Funder Contacts
    • Science Officer: Susan Azrin
    • Program Official: Michael Freed
    • Grants Management Official: Jackie Chia
  • Awarded Budget (Total Cost)
    • Year 1: $2,220,745
    • Year 2: $2,052,966
    • Year 3: $2,035,335
    • Year 4: $2,000,066
    • Year 5: $1,967,876

Documents & Reports

  • IRB Review
    • KPWA IRBnet file: [ 1475733 ]
    • KPWA IRB is single IRB reviewing for BSWH, HPHC, HPI, KPNC, KPNW, and KPSC.
    • EIRH, HFHS, KPCO, (KPGA?), KPHI, and PAMF IRB determination that work is exempt.
    • GSU and UW IRB determination that work is research not involving human subjects.

Personnel Contact List

Funded feasibility pilot projects

Publications

Autism Registry

Project Name:
A Diverse Autism Registry for Effectiveness Studies     
Principal Investigator:
Lisa Croen, PhD
Principal Investigator Contact Information:
lisa.a.croen@kp.org
Funder
NIMH
Funding Period:
08/2011 – 07/2013
Abstract:
The overarching goal of this research proposal is to create a large, comprehensive and dynamic autism spectrum disorder (ASD) registry across several integrated health systems participating in the Mental Health Research Network (MHRN). This registry will enable rapid identification and enrollment of patients into future large-scale comparative effectiveness studies testing treatment, preventive and services interventions, as well as future pharmacogenomic and etiologic investigations. We will leverage the many unique resources provided by the MHRN, including: 1) the large and ethnically diverse population of children with ASD, who are representative of the communities served by the health plans, 2) comprehensive electronic medical records (EMR) systems which capture all patient interactions with the health plans, 3) the existing biospecimen repositories at some participating sites that will facilitate collection of genetic material from children and their family members, and 4) researchers with an established track record of engaging and enrolling patients in autism clinical research studies and extensive experience in conducting research using electronic databases.
Grant Number:
 U19MH092201
Participating Sites:
Kaiser Permanente Northern California, Oakland, CA (Lead Site)
Harvard Pilgrim Health Care, Boston, MA
Kaiser Permanente Georgia, Atlanta, GA
Kaiser Permanente Northwest, Portland, OR
Kaiser Permanente Southern California, Pasadena, CA
Investigators:
Lisa Croen, PhD (Lead)
Jeanne Madden, PhD
Ashli Owen-Smith, PhD
Frances Lynch, PhD
Karen Coleman, PhD
Virginia Quinn, PhD
Major Goals: Build a comprehensive and dynamic registry of children with an autism spectrum disorder receiving healthcare from one of the participating health plans. Collect survey data from a subset of these families regarding ASD services and treatments utilized and associated costs and perception of efficacy; quality of life; caregiver strain; coordination of care; and resource and educational needs. Establish a biospecimen bank for future research studies
Description of study sample:
The initial sample for development of the ASD registry included all members aged 0-17 with any recorded ASD diagnosis.  1272 chart reviews were completed to validate ASD diagnosis at 5 study sites, and 1155 families completed online surveys at 4 sites.
Current Status: Completed an ASD diagnostic validation study, ascertained children with ASD and built the registryCompleted the survey and collection of biospecimensCurrently, we are working on several manuscripts using registry and survey data. Work on this subject continues on a related MHRN project, “Maximizing Biospecimen Collection for Childhood Disorders
Study Registration: 
N/A
Publications:
Coleman KJ, Lutsky MA, Yau V, Qian Y, Pomichowski ME, Crawford PM, et al. Validation of autism spectrum disorder diagnoses in large healthcare systems with electronic medical recordsJ Autism Dev Disord.2015 Jul; 45(7):1989–96. doi: 10.1007/s10803-015-2358-0.Cummings, JR, Lynch, FL, Rust, KC, Coleman, KJ, Madden, JM, Owen-Smith, AA, et al. Health Services Utilization Among Children With and Without Autism Spectrum DisordersJ Autism Dev Disord. 2015 Nov; 46: 910-920. Doi: 10.1007/s10803-015-2634-z.Madden, J.M., Lakoma, M.D., Lynch, F.L. et al. Psychotropic Medication Use among Insured Children with Autism Spectrum DisorderJ Autism Dev Disord. 2016: 1-11. doi:10.1007/s10803-016-2946-7.Owen-Smith, AA, Bent, S, Lynch, FL, Coleman, KJ, Yau, YM, Pearson, KA, Massolo, ML, et al. Prevalence and predictors of complementary and alternative medicine use in a large insured sample of children with Autism Spectrum Disorders. Res Autism Spectr Disord. 2015 Sept 1; 17: 40-51. doi: 10.1016/j.rasd.2015.05.002.Becerra, T, Massolo, M, Yau, V, Owen-Smith, A, Lynch, F, et al. A Survey of Parents with Children on the Autism Spectrum: Experience with Services and TreatmentsThe Permanente Journal.  2017;21. doi: 10.7812/TPP/16-009.Becerra-Culqui TA, Lynch FL, Owen-Smith AA, Spitzer J, Croen LA. Parental First Concerns and Timing of Autism Spectrum Disorder Diagnosis. J Autism Dev Disord. 2018 Oct;48(10):3367-3376. doi: 10.1007/s10803-018-3598-6. PubMed PMID:29754290.
Resources:
N/A
Lessons Learned: Health plan databases can be used to identify a large number of children with a valid ASD diagnosis. In order to achieve a high response rate to the survey, more resource-intense and tailored contact strategies are necessary. Among families participating in the survey, a very high percentage agreed to donate a biospecimen
What’s next?
Working on new manuscripts.

Firearms means restriction for suicide prevention in pediatric primary care

Project Name:
Intervention mapping to develop multi-level implementation strategies in partnership with stakeholders: Firearms means restriction for suicide prevention in pediatric primary care
Principal Investigator:
Rinad Beidas, PhD
Principal Investigator Contact Information:
rbeidas@upenn.edu
Principal Investigator institution:
University of Pennsylvania
Funder:
NIMH
Funding Period:
05/2016 – 07/2018
Abstract:
Suicide is a leading cause of death in children and adolescents and a critical public health concern. One promising suicide prevention strategy that is under-utilized includes reducing access to lethal means, or means restriction. Firearms are an important target for means restriction given that 1 in 3 homes possess a firearm and firearms are the most lethal manner by which suicide is attempted. Primary care is an ideal setting in which to provide firearms means restriction given that almost half of youth who die by suicide do not access specialty mental health services in the 12 months preceding their attempt. The Safety Check intervention is an evidence-based practice for implementing firearms means restriction in pediatric primary care (including pediatrics, family medicine, and adolescent medicine). Despite the existence of this intervention and recommendations from the American Academy of Pediatrics, providers rarely discuss means restriction or firearms during visits, suggesting the need for a better understanding of the barriers and facilitators to implementing means restriction in pediatric primary care. Implementation science frameworks, including the Consolidated Framework for Implementation Research (CFIR), suggest the importance of attending to multiple levels of context during implementation, including provider (e.g., self-efficacy), organizational (e.g., expectations about provider behavior), system (e.g., prompts in the electronic health records), and intervention (e.g., acceptability) factors. The NIMH-funded Mental Health Research Network (MHRN), a consortium of 13 healthcare systems across the United States, affords a unique opportunity to better understand how to implement means restriction in pediatric primary care from a system-level perspective. Our objective in this application is to collaboratively develop implementation strategies in partnership with MHRN stakeholders to increase the use of means restriction in pediatric primary care. In Aim 1, we will survey leadership and primary care providers of 96 primary care practices within 2 MHRN systems (Henry Ford Health System and Baylor Scott & White Health) to understand acceptability and use of the three components of the Safety Check intervention (i.e., screening, brief counseling around gun safety, and provision of gunlocks). In Aim 2, in collaboration with MHRN stakeholders in these 2 systems, we will use intervention mapping and the CFIR to systematically develop and evaluate a multi-level menu of implementation strategies for firearm means restriction in pediatric primary care. The proposed work is consistent with the NIMH strategic plan, specifically Objective 4, to strengthen the public health impact of NIMH-supported research, and will lead to a hybrid effectiveness-implementation R01 proposal. The long-term goal of this line of research is to reduce death by suicide by increasing the use of evidence-based strategies in pediatric primary care while also promoting multi-level implementation strategies informed by a systematic and rigorous development approach.
Grant Number:
1R21MH109878-01
Participating Sites:
Henry Ford Health System
Baylor Scott & White Health
Investigators:
Rinad Beidas, PhD
Brian Ahmedani, PhD
John Zeber, PhD
Steven Marcus, PhD
Courtney Benjamin Wolk, PhD
Shari Mintz, PhD
Joel Fein, MD, MPH
Gregory Brown, PhD
Major Goals:
To partner with MHRN stakeholders and engage in quantitative and qualitative inquiry around how to implement an evidence-based program for firearm safety as a suicide prevention strategy for youth in primary care.
Description of study sample: The sample for Aim 1 includes leaders from HFHS and BSW; and primary care providers from HFHS and BSW. 204 PCPs and 57 CLs were eligible for the survey; 103 (50.4%) PCPs and 40 (70.2%) CLs participated. The sample from Aim 2 includes 4-12 individuals from each of the following stakeholder groups (n=70): parents of youth that receive pediatric primary care at a HFHS clinic; physician providers; non-physician providers; leaders of primary care practices; leaders of behavioral health; leaders of quality improvement; system leaders; third-party payers, members of national credentialing bodies, and gun-owning constituents.
Current Status:9/27/18
Aim 1:
We collected quantitative primary data about the acceptability and use of the three EBPs in the survey, as reported previously. We also collected secondary data via publicly available data sources, including data from the MHRN virtual data warehouse and the National Center for Health Statistics’ National Vital Statistics System. Additionally, we extracted youth (aged 12-24) suicide deaths over the past five years by firearm at the county level for each primary care practice location from the National Vital Statistics System. We have submitted the manuscript summarizing Aim 1 findings, and it is currently under peer review. Aim 2:
We trained research staff and successfully conducted qualitative interviews for all stakeholder groups (n=70). We added a stakeholder group (gun-owning constituents) given our experiences with the qualitative interviews. We have completed all interviews and enrolled 7 parents, 7 primary care physicians, 7 non-physician providers, 7 clinical leaders, 6 system leaders, 6 leaders of behavioral health, 7 leaders of quality improvement, 4 third-party payers, 7 members of national credentialing bodies, and 12 gun owners. We evaluated all interviews to identify common themes related to barriers, facilitators, and implementation strategies. Upon gathering this information, we used the spirit of intervention mapping, in concert with the Consolidated Framework for Implementation Research (CFIR), to inform the development of a menu of implementation strategies. All interviews were transcribed and loaded into NVivo software for data management. Our team developed two different comprehensive coding schemes, one for the original set of stakeholders and one for gun-owner constituents, given that different themes emerged. We completed coding of all transcripts, and the coders maintained excellent reliability. From the interviews, we gleaned a number of themes around barriers, facilitators, and implementation strategies regarding the potential implementation of our intervention of interest. Overall, the interviews underscored the importance of considering how to best support providers to improve their self-efficacy and implement new practices (e.g. providing ongoing consultation, leveraging existing mental health screening/ suicide prevention initiatives), since providers are already overextended and have little time to implement additional practices. The manuscript is currently under review. Currently, we are preparing a manuscript specifically detailing the views of the gun-owner constituents,.Through the use of intervention mapping, we developed a list of implementation strategies, based off feedback from stakeholders who completed the qualitative interviews. After compiling the list, we returned to those original stakeholders and asked them to complete a brief online survey assessing feasibility, acceptability, and importance of each strategy. In total, we received 35 responses (roughly 69%). By administering the online survey, we were able to generate a refined list of the most feasible and acceptable implementation strategies under each level. We are currently drafting a manuscript that describes how our team selected the implementation strategies, using the process of intervention mapping.
Study Registration:
N/A
Publications:
Wolk CB, Jager-Hyman S, Marcus SC, Ahmedani BK, Zeber JE, Fein JA, Brown GK, Lieberman A, Beidas RS. Developing implementation strategies for firearm safety promotion in paediatric primary care for suicide prevention in two large US health systems: a study protocol for a mixed-methods implementation study.  BMJ Open. 2017 Jun 24;7(6):e014407. doi: 10.1136/bmjopen-2016-014407.Jager-Hyman, S., Wolk, C. B., Ahmedani, B. K., Zeber, J. E., Fein, J. A., Brown, G. K., Byeon, Y. V., Listerud, H., Gregor, C. A., Lieberman, A., & Beidas, R. S. (in press). Perspectives from firearm stakeholders on firearm safety promotion in pediatric primary care as a universal suicide prevention strategy: A qualitative study. Journal of Behavioral Medicine.
Beidas, R. S., Jager-Hyman, S., Becker-Haimes, E., Wolk, C., Ahmedani, B., Zeber, J., Fein, J., Brown, G., Gregor, C., Lieberman, A., & Marcus, S.: Acceptability and use of evidence-based practices for firearm storage in pediatric primary care. Academic Pediatrics. November 2018.Wolk, C. B., Van Pelt, A., Jager-Hyman, S., Ahmedani, B., Zeber, J., Fein, J., Brown, G., Gregor, C., Lieberman, A., & Beidas, R. S.: Stakeholder perspectives on implementing a firearm safety intervention in pediatric primary care as a universal suicide prevention strategy: A qualitative study. JAMA Network Open. November 2018.Beidas, R.: How your child’s primary-care doctor can prevent gun injury and death. Philly.com. December 2018. (OP ED)
Resources:
N/A
Lessons Learned:
N/A
What’s next?
We will submit an application to NIMH in 2019 to conduct a hybrid trial evaluating both the effectiveness of the adapted Safety Check in pediatric primary care and the implementation strategies we use to implement it.

Maximizing Biospecimen Collection for Childhood Disorders

Project Name:
Maximizing Biospecimen Collection for Childhood Disorders
Principal Investigator:
Lisa Croen, PhD
Principal Investigator Contact Information:
lisa.a.croen@kp.org
Principal Investigator institution:
Kaiser Permanente Northern California, Oakland, CA
Funder
NIMH
Funding Period:
07/2015– 06/2018
Abstract:
Autism Spectrum Disorder (ASD) and Bipolar Disorder (BD) are the two most common severe mental disorders affecting children and adolescents.  Few evidence-based treatments exist for either condition.  Furthermore, response to treatment varies widely between individuals – and no evidence exists to match individual children with specific treatments.  Research to address these gaps – both to develop new treatments and to more effectively match individuals with treatments – will isolating on identifying biomarkers or endophenotypes that can accurately identify more homogeneous subgroups of patients and genetically related family members.  This next generation of research will require collecting biospecimens from large and representative samples of families affected by childhood mental disorders and linking those specimens to comprehensive and longitudinal health records. The main aim of this pilot is to identify the best ways to maximize biospecimen collection from children with mental health conditions.  We plan to meet this goal by leveraging and extending our work during the first cycle of MHRN funding on the feasibility of biospecimen collection from families of children with Autism Spectrum Disorder (ASD).  We will use a mixed methods approach to develop low-cost, tailored recruitment and consenting processes that specifically address concerns about participating in studies using biospecimens from children with mental health conditions and that are appropriate to large and diverse populations.  
Grant Number:
U19MH092201
Participating Sites:                                       Kaiser Permanente Northern California, Oakland, CA (Lead Site)Kaiser Permanente Georgia, Atlanta, GAKaiser Permanente Northwest, Portland, OR
Investigators:
Lisa Croen, PhD
Ashli Owen-Smith, PhD
Frances Lynch, PhD
Major Goals: Specific Aim 1: Using data from a feasibility study of biospecimen collection conducted during the first cycle of MHRN funding and health system electronic medical record (EMR) data, we will examine the demographic and clinical characteristics of children and their families predicting successful recruitment of families to participate in biospecimen collection. Specific Aim 2: Explore knowledge, attitudes and beliefs about biobanking and perceived facilitators and barriers to biobank participation among parents of children with mental health conditions from diverse backgrounds using ethnographic/qualitative methods (interviews, focus groups). Specific Aim 3: a) Develop tailored methods for recruiting and consenting children/adolescents with mental health conditions and their families into a biospecimen bank for future research) Develop a strategy for pilot testing those methods across different pediatric mental health conditions.  Focus on low-cost methods appropriate for large and diverse populations
Description of study sample:
Fifteen families who participated in the MHRN1 study at each of the three study sites, for a total of 45 ASD interviews and 15 families who have a child with a bipolar disorder diagnosis at KPNC, for a grand total of 60 families.
Current Status:
Aim 1: Completed data analysis.Aim 2: Data analysis was completed. Manuscript has been drafted and is expected to be submitted for publication in the Fall of 2019.
Study Registration:15 ASD families have been recruited at KPGA15 ASD families have been recruited at KPNW30 families (15 ASD and 15 Bipolar) families have been recruited at KPNC.
Publications:
Manuscript for Aim 2 to be submitted for publication in the Fall of 2019.
Resources:
N/A
Lessons Learned:
In spite of the profound caregiver burden experienced by many parents of children with serious mental health-related issues, participants in the present study were eager to participate in research, in general, and in biospecimen research, in particular, as long as the research process involved trust, clarity, and flexibility. Researchers working with these populations need to make it easy for families to participate – even if that is less convenient and more costly for them – and should prioritize the sharing of knowledge gained by the research with participants at the end of the study.
What’s next? Working on new manuscripts.